Atlas of Fetal Pathologies

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Agenesis of the corpus callosum (ACC)

Absent corpus callosum, Dysgenesis of the corpus callosum
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How to cite this entry

Odackal NJ. Agenesis of the corpus callosum (ACC). In: Atlas of Fetal Pathology [Internet]. 2026 Sep 3 [cited 2026 Oct 15]. Available from: https://fetalatlas.org/entry/agenesis-of-the-corpus-callosum/

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Key notes

  • Is not a life threatening condition
  • Does increase risk of not meeting several developmental milestones
  • May not be an isolated finding
  • Will benefit from additional evaluation
  • May require NICU admission and delay in discharge

What this means for your baby

  • ACC means the connection between the two sides of the brain did not fully form
  • Many babies do well; outcomes depend on whether other findings are present
  • Your baby will have extra evaluation after birth and follow-up with a neurologist

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References

  1. Haisley LD, Hantzsch L, Glick AR, Turner J, Sung S, Swanson MR, et al. Adaptive functioning development in infants with agenesis of the corpus callosum. Pediatrics. 2025 May 1;155(5):e2024066555. doi: 10.1542/peds.2024-066555Link
  2. Society for Maternal-Fetal Medicine (SMFM); Rotmensch S, Monteagudo A. Agenesis of the corpus callosum. Am J Obstet Gynecol. 2020 Dec;223(6):B17-B22. doi: 10.1016/j.ajog.2020.08.179Link
  3. Hahn JS, MacLean J, Yeom K. Agenesis of corpus callosum and associated malformations. NeoReviews. 2012 Apr;13(4):e224-32. doi: 10.1542/neo.13-4-e224Link
  4. Tsai P, Shinar S. Agenesis of the corpus callosum: what to tell expecting parents? Prenat Diagn. 2023 Nov;43(12):1527-35. doi: 10.1002/pd.6447Link

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